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HomeMy WebLinkAboutTHE COLORADO STATE UNIVERSITY SYSTEM - CONTRACT - AGREEMENT MISC - THE COLORADO STATE UNIVERSITY SYSTEMUpdated 11-7-12 1 SERVICE AGREEMENT This Service Agreement (“Agreement”) is entered into by and between The Board of Governors of The Colorado State University System, acting by and through Colorado State University, an institution of higher education of the State of Colorado, located at Fort Collins, Colorado, 80523- 2002 (“University”), and the Sponsor, City of Fort Collins (“Sponsor”), collectively referred to as “Parties” and is effective June 20, 2018. PARTIES: UNIVERSITY: SPONSOR: The Board of Governors of the Colorado State University System, acting by and through Colorado State University, an institution of higher education of the State of Colorado, located at Fort Collins, Colorado, 80523-2002 Sponsored Programs 601 Howes Street Room 408 Fort Collins, CO 80525-2002 Full legal name of Sponsor: City of Fort Collins State of Business Registration: Colorado Business Address: 1745 Hoffman Mill Rd City, State, Zip: Fort Collins, CO 80522 RECITALS: 1. University is a comprehensive, land-grant University with experience and resources in a field of mutual interest between University and Sponsor. 2. Sponsor desires services to be performed in accordance with the Scope of Work described in Exhibit A and terms outlined in this Agreement (the “Project”). 3. Performance of such services is consistent, compatible, and beneficial to the academic role and mission of the University as an institution of higher education. AGREEMENT: 1. Independent Contractors. It is understood and agreed by the Parties that the University is an independent contractor with respect to the Sponsor and that this Agreement is not intended and shall not be construed to create an employer/employee relationship or a joint venture relationship between the University and the Sponsor. The University shall be free from the direction and control of the Sponsor in the performance of the University’s obligations under this Agreement, except that the Sponsor may indicate specifications, standards requirements and deliverables for satisfaction of the University’s obligations under this Agreement. 2. Term. This Agreement shall begin on June 12, 2018 and shall terminate on September 30, 2018 unless sooner terminated as provided herein or extended by written agreement of the Parties. 3. Scope of Work. The University agrees to perform the services activities described in the Project and made a part hereof as Exhibit A, under the direction and supervision of the University DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 2 Principal Investigator and in accordance with any milestones or periodic deliverables specified in Exhibit A. The University Principal Investigator is Gregory Ebel of the Department of Microbiology, Immunology, and Pathology who will be responsible for the technical direction of the Project. 4. Payment. The Sponsor agrees to pay the University for the Project performed under this Agreement in a fixed price amount of Thirty-Eight Thousand Five Hundred Twenty-Four Dollars, ($38,524) payable fifty percent (50%) Nineteen Thousand Two Hundred Sixty-Two Dollars ($19,262) upon execution; twenty-five percent (25%) Nine Thousand Six Hundred Thirty-One Dollars ($9,631) at mid-project (August 2018); and twenty-five percent (25%) Nine Thousand Six Hundred Thirty-One Dollars ($9,631) upon University’s submission of all deliverables. If the Sponsor uses a purchase order or some other source document as a Sponsor method for paying invoices from the University and the purchase order or source document contains terms and conditions, those terms and conditions will be null and void and not applicable to this Agreement. The purchase order or source document is solely an internal Sponsor payment document. 5. Reporting Requirements. The University will provide reports on the progress of the services as required in the Scope of Work, Exhibit A. 6. Confidentiality. (a) Parties may have certain documents, data, information, and methodologies that are confidential and proprietary to that Party (“Confidential Information”). During the term of this Agreement, either Party may, as the “Disclosing Party,” disclose its Confidential Information to the other Party (the “Recipient”), in writing, visually, or orally. If submitted other than in writing, the Confidential Information shall be reduced to writing within 30 working days. Recipient shall receive and use the Confidential Information for the sole purpose of the performance of this Agreement, and for no other purpose (except as may be specifically authorized by the Disclosing Party, in writing). Recipient agrees not to make use of the Confidential Information except for services conducted under this Agreement and agrees not to disclose the Confidential Information to any third Party or Parties for a period of three (3) years after the end of this Agreement without the prior written consent of the Disclosing Party (b) Recipient shall use reasonable efforts to preserve the confidentiality of the Confidential Information (using the same or similar protections as it would as if the Confidential Information were Recipient’s own, and in any event, not less than reasonable care). Recipient shall obligate its affiliates with access to any portion of the Confidential Information to protect the proprietary nature of the Confidential Information at least to the extent set forth in this Section 6. (c) “Confidential Information” shall not include, and Recipient shall have no obligation to refrain from disclosing or using, information which: is generally available to the public at the time of this Agreement; becomes part of the public domain or publicly known or available by publication or otherwise, not through any unauthorized act or omission of DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 3 Recipient; is lawfully disclosed to the Recipient by third Parties without breaching any obligation of non-use or confidentiality; or has been independently developed by persons in Recipient’s employ, as proven with written records, or otherwise who have no contact with Confidential Information. (d) In the event that Recipient is required by law to disclose Confidential Information, Recipient will promptly notify the Disclosing Party, and the Disclosing Party may, at its sole discretion and expense, initiate legal action to prevent, limit or condition such disclosure. (e) Notwithstanding any other provision of this Agreement, a Party may retain one copy of the other Party’s Confidential Information in its confidential files, for the sole purpose of establishing compliance with the terms hereof. 7. Publication. The University, as a state institution of higher education, engages only in activities that are compatible, consistent, and beneficial to its academic role and mission. Therefore, results of such activities must be reasonably available for publication and the Parties acknowledge that the University shall have the right to publish results. The University agrees, however, that during the term of this Agreement and for six (6) months thereafter, the Sponsor shall have forty-five (45) days to review and comment on any proposed publication. Should Sponsor believe that any part of such publication would constitute the disclosure of Confidential Information as defined in Paragraph six above or if Sponsor does not wish to have its name associated with the publication, Sponsor will notify University in writing within such forty-five (45) day period. University shall remove any Sponsor Confidential Information or remove the name and/or reference to Sponsor from the publication. The offer to omit Sponsor’s name will not apply if in the reasonable opinion of the University, the publication is necessary to alert the community of a significant public safety concern or for the protection of one or more members of the public. 8. Equipment. Unless otherwise provided in the Scope of Work or in a writing signed by the Parties, all equipment purchased with funds provided under this Agreement for use in connection with this Agreement shall be the property of the University, and shall be dedicated to providing services under this Agreement while this Agreement is in effect. 9. Liability; Insurance. Each Party hereto agrees to be responsible for its own wrongful or negligent acts or omissions, or those of its officers, agents, or employees to the full extent allowed by law. Liability of the University and the Sponsor is at all times herein strictly limited and controlled by the provisions of the Colorado government Immunity Act, C.R.S. §§ 24-10-101, et seq. as now or hereafter amended. Nothing in this Agreement shall be construed as a waiver of the protections of said Act. Each Party represents and warrants that it maintains comprehensive general liability insurance and all coverages required by law sufficient for the purpose of carrying out the duties and obligations arising under this Agreement. A Party will furnish the other Party a certificate evidencing such insurance upon written request. 10. Exclusive Warranty; Disclaimer. University warrants that all deliverables provided under this Agreement will be provided substantially in accordance with the Scope of Work and/or written protocol provided by Client. All other warranties, express and implied, are hereby expressly disclaimed INCLUDING WARRANTIES OF MERCHANTABILITY AND DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 4 FITNESS FOR A PARTICULAR PURPOSE. University does not perform any services under this agreement that may be subject to FDA Regulations, e.g. GMP, cGMP, GLP, GCP work/services. University shall not be liable for any indirect, special, incidental, consequential or punitive loss or damage of any kind, including but not limited to lost profits (regardless of whether or not University knows or should know of the possibility of such loss or damages). The liability of either party under this Agreement shall not exceed the amount paid or payable to the University under this Agreement. 11. Use of Tradenames and Service Marks. Neither Party obtains by this Agreement any right, title, or interest in, or any right to reproduce or to use for any purpose, the name, tradenames, trade- or service marks, or logos (the “Marks”), or the copyrights of the other Party. Neither Party will include the name of the other Party or of any employee of that Party in any advertising, sales promotion, or other publicity matter without the prior written approval of that other Party. In the case of the University, prior written approval is required from the University Vice President for Research. In the case of the Sponsor, prior written approval is required from an authorized representative of the Sponsor. 12. Termination. Either Party may terminate this Agreement, without cause, upon not less than sixty (60) days' written notice, given in accordance with the Notice provisions of this Agreement. Termination of this Agreement shall not relieve a Party from its obligations incurred prior to the termination date. Upon termination of this fixed price Agreement, the Sponsor will pay a pro rata share of the Agreement. This will be calculated by adding the start up costs (which include category/cost N/A) plus the total Project budget divided by the total number of days of the Agreement (which will give a cost per day) and at that point multiplied by the number of days the Agreement was in force including the 60 days after the termination notice. 13. Default. A Party will be considered in default of its obligations under this Agreement if such Party should fail to observe, to comply with, or to perform any term, condition, or covenant contained in this Agreement and such failure continues for thirty (30) days after the non-defaulting Party gives the defaulting Party written notice thereof. In the event of default, the non-defaulting Party, upon written notice to the defaulting Party, may terminate this Agreement as of the date specified in the notice, and may seek such other and further relief as may be provided by law. Notwithstanding the foregoing, in the event of a breach or threatened breach of paragraph 6 of this Agreement, the non-defaulting Party may terminate the Agreement immediately without affording the defaulting Party the opportunity to cure, and may seek an injunction or restraining order as required to prevent unauthorized disclosures of Confidential Information or unauthorized use of its Marks or copyrights. 14. Late Charges; Expenses. All amounts payable by Sponsor to CSU under this Agreement shall be paid to CSU without any setoff, deduction or counterclaim. Any amounts billed to Sponsor not paid within five (5) days of the due date thereof may be subject to a late charge of five percent (5%) of the amount billed. In addition, such unpaid amount may bear interest until paid at the rate of eighteen percent (18%) per annum. In the event any payment from Sponsor by check is returned by the financial institution on which it is drawn for any reason, a service charge of One Hundred Dollars ($100.00) shall be due and payable in addition to the late charge set forth above. In the event of any default by Sponsor hereunder, Sponsor shall pay to CSU all attorneys' fees incurred by CSU in connection with such default or the enforcement of CSU's rights or remedies arising in DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 5 connection therewith, whether or not this Agreement is terminated and whether or not CSU institutes any lawsuit against Sponsor as a result of such default. 15. Notices. All notices and other correspondence related to this Agreement shall be in writing and shall be effective when delivered by: (i) certified mail with return receipt, (ii) hand delivery with signature or delivery receipt provided by a third-Party courier service (such as FedEx, UPS, etc.), (iii) fax transmission if verification of receipt is obtained, or (iv) email with return receipt, to the designated representative of the Party as indicated below. A Party may change its designated representative for notice purposes at any time by written notice to the other Party. The initial representatives of the Parties are as follows: University: Sponsor: Julie Harvey Sponsored Programs 408 University Services Center 601 So. Howes Street Colorado State University Fort Collins, CO 80523-2002 Telephone: (970) 491-491-1560 E-mail Julie.harvey@colostated.edu City of Fort Collins Natural Areas Department P.O. Box 580 Fort Collins, CO 80522-0580 Attn: Matt Parker Telephone: (970) 416-2433 E-mail: mparker@fcgov.com 16. Legal Authority. Each Party to this Agreement warrants that it possesses the legal authority to enter into this Agreement and that it has taken all actions required by its procedures, bylaws, and/or applicable law to exercise that authority, and to lawfully authorize its undersigned signatory to execute this Agreement and to bind it to its terms. The person(s) executing this agreement on behalf of a Party warrant(s) that such person(s) have full authorization to execute this Agreement. This Agreement shall not be binding upon Colorado State University, its governing board or the State of Colorado unless signed by the University Vice-President for Research or his/her authorized delegate. 17. Entire Agreement; Changes and Amendments. This Agreement constitutes the entire agreement between the Parties, and supersedes any previous contracts, understandings, or agreements of the Parties, whether verbal or written, concerning the subject matter of this Agreement. No amendment to this Agreement shall be valid unless it is made in a writing signed by the authorized representatives of the Parties. 18. Governing Law, Jurisdiction and Venue. Each Party agrees to comply with all applicable federal, state and local laws, codes, regulations, rules, and orders in the performance of this Agreement. This Agreement shall be governed by and construed under the laws of the State of Colorado. Any claim arising under this Agreement shall be filed and tried in a court of competent jurisdiction in the City and County of Denver, State of Colorado. 19. Assignment. This Agreement shall not be assigned without the prior written consent of the other Party, which consent shall not be unreasonably withheld or delayed, provided however, such consent shall not be required in the case of a sale or transfer to a third Party of all or DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 6 substantially all of a Party’s business. Subject to the foregoing, this Agreement shall inure to the benefit of and be binding on the successors and permitted assigns of the Parties. 20. Export of Technology. It is understood that University and Sponsor are subject to United States laws and regulations controlling the export of technical data, computer software, laboratory prototypes and other commodities, and that obligations hereunder are contingent on compliance with applicable U.S. export laws and regulations (including the Arms Export Control Act, as amended, and the Export Administration Act of 1979). The transfer of certain technical data and commodities may require a license from the cognizant agency of the United States Government and/or written assurances that such data or commodities will not be exported to certain foreign countries without prior approval of the cognizant government agency. Sponsor and University agree to cooperate in securing any license which the cognizant agency deems necessary in connection with this Agreement. Sponsor shall notify University if any data or materials to be supplied to University by Sponsor are subject to export control license requirements or are listed under export control regulations. 21. Waiver and Severability. No waiver of any breach of any provision of this Agreement shall operate as a waiver of any other or subsequent breach thereof or of the provision itself, or of any other provision. No provision of this Agreement shall be deemed to have been waived unless such waiver is in writing and signed by the Party waiving the same, with the signature on behalf of University being that of a vice president of University. If any provision of this Agreement is determined to be invalid or unenforceable in whole or in part, such invalidity or unenforceability shall attach only to such provision or part thereof and the remaining part of such provision and all other provisions hereof shall continue in full force and effect. 22. Conflict of Interest. Except as set forth herein, Sponsor certifies that no officer, employee, student or agent of University has been employed, retained, or paid a fee, or has otherwise received or will receive during the term of this Agreement any personal compensation or consideration by or from Sponsor or any of Sponsor's directors, officers, employees, or agents in connection with the obtaining, arranging, negotiation or conducting of this Agreement without advance, written notification to the University. 23. Public Contracts for Service. CRS §8-17.5-101. Each party certifies, warrants, and agrees that it does not knowingly employ or contract with an illegal alien who will perform work under this contract and will confirm the employment eligibility of all employees who are newly hired for employment in the United States to perform work under this contract, through participation in the E-Verify Program or the Department program established pursuant to CRS §8- 17.5-102(5)(c), each party shall not knowingly employ or contract with an illegal alien to perform work under this contract or enter into a contract with a subcontractor that fails to certify that the subcontractor shall not knowingly employ or contract with an illegal alien to perform work under this contract. Each party (a) shall not use E-Verify Program or Department program procedures to undertake pre-employment screening of job applicants while this contract is being performed, (b) shall notify the subcontractor and the contracting State agency within three days if they have actual knowledge that a subcontractor is employing or contracting with an illegal alien for work under this contract, (c) shall terminate the subcontract if a subcontractor does not stop employing or contracting with the illegal alien within three days of receiving the notice, and (d) shall comply with reasonable requests made in the course of an investigation, undertaken pursuant to CRS §8- DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 7 17.5-102(5), by the Colorado Department of Labor and Employment. If either party fails to comply with any requirement of this provision or CRS §8-17.5-101 et seq., the contracting State agency, institution of higher education or political subdivision may terminate this contract for breach. 24. Subcontractors. The University may not subcontract any of the Work set forth in the Exhibit A, without the prior written consent of the Sponsor, which shall not be unreasonably withheld. 25. Headings. Paragraph headings are for reference and convenience only and shall not be determinative of the meaning or the interpretation of the language of this Agreement. 26. Survival. The respective rights and obligations of University and Sponsor under Paragraphs 7, 10, 11 and 20 shall survive the expiration or earlier termination of this Agreement. IN WITNESS WHEREOF, the Parties have executed this Agreement the day and year written below. The Board of Governors of the Colorado State University System, acting by and through Colorado State University: By: Printed Name: Title: Date: Sponsor: City of Fort Collins By: Printed Name: Title: Date: DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Associate Director, Sponsored Programs David Doty 6/21/2018 Purchasing Director Gerry Paul 6/21/2018 Updated 11-7-12 8 EXHIBIT A TO SERVICE AGREEMENT Scope of Work Project Proposal (#139340) Testing of Mosquito Pools for West Nile Virus, City of fort Collins, 2018 BACKGROUND West Nile virus (WNV) first appeared in Colorado in 2002. Since that time, CO, particularly the northern Front Range counties (Larimer, Weld, Boulder), have seen WNV disease cases in humans in every year. Case data for Fort Collins are not available, but it is reasonable to assume that a significant proportion of Larimer County cases occurred in Fort Collins (FC), Loveland (LV) and Berthoud residents. In Larimer County, the annual number of cases reported has ranged from a high of 546 in 2003 to a low of a single case in 2011, with a total of 946 cases to date (Table 1). This represents 17% of the total cases reported. Larimer County generally reports a disproportionally large percent of all WNV cases in CO. Table 1. Reported West Nile virus infections in humans, 2003-2017, Larimer County and statewide, including severe (neuroinvasive) and fatal case numbers. Data from Colorado Dept. of Health and Environment, as of 12/2017 . 1 Includes encephalitis, meningitis, and flaccid paralysis. Larimer County Colorado County cases Neuro- invasive 1 cases Fatalities State cases Neuro- invasive 1 cases Fatalities % of cases in CO that occurred in Larimer Co. 2002 0 0 0 13 0 0 0.0 2003 546 64 10 2,947 622 66 18.5 2004 17 1 0 291 41 4 5.8 2005 13 2 0 106 21 2 12.3 2006 42 7 1 345 65 7 12.2 2007 94 4 0 578 100 7 16.3 2008 13 3 1 71 17 1 18.3 2009 25 10 0 103 35 3 24.3 2010 13 3 0 81 26 4 16.0 2011 1 0 0 7 2 0 14.3 2012 8 3 0 131 62 5 6.1 2013 89 17 1 320 90 7 29.0 2014 18 3 0 114 45 5 15.8 2015 21 6 0 108 57 3 19.4 2016 32 5 0 148 58 8 21.6 2017 14 3 2 68 29 4 20.6 Total 946 131 15 5,431 1,270 126 16.7 DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 9 FC responded to the emergence of WNV in 2003 by establishing a surveillance and control program. The surveillance involves extensive monitoring of potential larval mosquito habitats and weekly collection and testing of adult Culex mosquitoes for WNV. Primary components of the control portion of the program are source reduction, larviciding and public education. Adulticiding is reserved as an option to be used under exceptional levels of WNV activity within FC. Data from the adult trapping and testing program is essential to deciding if, where, and when adulticiding is necessary in FC: adulticiding was conducted in 2003, 2007, in restricted zones in 2012, and city-wide in 2013. From 2003-2008 CDC provided WNV testing of FC mosquito pools at no charge. That service was no longer available beginning in 2009. Colorado State University (CSU) had been conducting studies of WNV along the Front Range, including virus testing. Thus, CSU could provide the testing service previously offered by the CDC at a competitive cost, and has done so successfully from 2009-2016. Resources available at CSU include trained staff and students, laboratory space in the Infectious Diseases Annex (IDA), equipment and reagents to perform RT-PCR detection of WNV, and standard laboratory equipment such as microscopes, freezers, incubators, etc. PROJECT PROPOSAL A. Period of contract The period of this contract shall extend from June 12 to September 30, 2018. The laboratory testing component of the project will take place from June 12 to August 31. Funding will continue until September 30 to permit data analyses and preparation of the final project report. B. Scope of work 1. Work plan a. Mosquito traps are operated weekly by City’s contractor. b. Mosquitoes are identified by contractor staff and Culex females (Culex tarsalis and Culex spp.) are placed in pools of up to 50 individuals, separated by collection site and collection date. CSU will provide the City’s contractor with standard vials to store and transport the mosquito pools (this eliminates the time-consuming task of transferring specimens once they arrive at IDA). c. Contractor delivers the weekly collection of pools to IDA according to an agreed upon schedule – typically early Thursday afternoon. Contractor provides lists of collections and pool numbers, and list of operational/non-operational traps for the week, in MS Excel format via e-mail attachment. d. IDA staff receives specimens and places in appropriate storage/refrigeration to await processing e. IDA staff conducts spot checks to identify mislabeling, missing pools, etc., then processes pools and performs RT-PCR testing f. IDA staff assembles and interprets PCR results. g. Weekly test results are combined with data provided by Contractor (see B.1.c, above) to produce tabular summaries, including comparison to historic patterns of vector and virus DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 10 activity (see D, below). h. Reports are sent to City of Fort Collins and to other organizations as needed. 2. Deliverables a. Up to 1,600 pools will be tested under the contract. b. Test results will be provided to City by 5 PM Monday of each testing week. Equivocal test results may result in delayed reporting, as accuracy is crucial to the surveillance process. i. Specimens must be received by Thursday at 2 PM for results to be available on Monday of the following week. ii. Pools will be processed in order of collection date (earliest collections processed first) unless otherwise requested by the City’s coordinator. iii. To obtain more rapid test results (e.g., when a sudden increase in virus activity is suspected) pools can be accepted early in the week for expedited testing. 3. Staffing a. PI Ebel, with support by Chet Moore as needed, will oversee day-to-day operation of the project, collate and interpret laboratory data, produce reports, and transmit reports to City of Fort Collins and other agencies as appropriate. b. Research Associate Michael Young will receive mosquito pools from contractor and prepare specimens according to protocol; perform RT-PCR testing; maintain laboratory notebooks documenting dates and times, pool numbers, results, and other relevant information; prepare summaries of tests; and deliver these results to the PI in a timely fashion. DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 11 C. Budget The budget covers West Nile virus testing only. It does not include testing for other potential pathogens of human or veterinary importance. Personnel Salary for PI Greg Ebel; 0.35 month $ 4,459 Salary for RA Michael Young; 1.45 month $ 3,839 Fringe cost for salaries $ 2,340 TOTAL PERSONNEL COST $10,638 Supplies Supplies cost for testing 1 pool for WNV = $15.24 * 1,600 pools $24,384 * See cost breakdown below Indirect Cost (based on 10.0% of the Modified Total Direct Cost) Indirect Cost $ 3,502 TOTAL BUDGET Direct Cost $35,022 Indirect Cost $ 3,502 GRAND TOTAL $38,524 Breakdown for cost of testing 1 mosquito pool for WNV Procedure Kit/Product Cost Each (Kit/bag ) n Cost / piec e # needed/ specime n Total Cost for Homogenizatio testing n Ball Bearings $35.00 425 $0.0 8 1 $0.08 Homogenizatio n 2mL tubes $69.27 500 $0.1 4 1 $0.14 RNA extraction MagMax Viral 96 5x $1,536.0 0 480 $3.2 0 1 $3.20 RNA extraction Chemicals (EtOH, etc) $0.30 RT-PCR Qiagen One Step $580.00 100 $5.8 0 1 $5.80 RT-PCR Primers $0.25 Electrophoresis Various (agarose, Updated 11-7-12 D. Reporting templates Based on the need to now report data not only for FC citywide but also separately for each of the four zones the city has been divided into for the purpose of WNV surveillance and mosquito control, CSU had to generate a new reporting template. This new reporting template is tailored to provide data relevant to the Level III and IV entomological triggers (see below) for control measures in the “City of Fort Collins Program Response Guidelines to Mosquito Borne Arboviral Activity (July 2008 edition)”. Level III  Vector index > 0.5 and increasing  Culex mosquito populations increasing and at or above historical average for that time period  Mosquito infection rates of > 3.0 per thousand (0.3%) and increasing Level IV  Vector index > 0.75.  Culex mosquito population above historical average for that time period  Sustained mosquito infection rates of > 5.0 per thousand (0.5%) Reporting templates are currently under revision. Note that CSU will provide reports in whatever format is deemed most useful to end users of our data. E. Reference material Vector Index CDC. 2013. West Nile Virus in the United States: Guidelines for Surveillance, Prevention, and Control. 4th Revision, June 14, 2013. http://www.cdc.gov/westnile/resources/pdfs/wnvguidelines.pdf The Vector Index is described on pages 63-66 (Appendix 2) in this document. VECTOR INDEX To express the arbovirus transmission risk posed by a vector population adequately, information from all three parameters (vector species presence, vector species density, vector species infection rate) must be considered. The Vector Index (VI) combines all three of the parameters quantified through standard mosquito surveillance procedures in a single value. The VI is simply the estimated average number of infected mosquitoes collected per trap night summed for the key vector species in the area. Summing the VI for the key vector species incorporates the contribution of more than one species and recognizes the fact that WNV transmission may involve one or more primary vectors and several accessory or bridge vectors in an area. DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 Updated 11-7-12 13 The Vector Index is expressed as: Maximum likelihood estimate for WNV infection rate per 1,000 females To account for uneven pool sizes (can range from 1-50 mosquitoes), we calculate a maximum likelihood estimate (MLE) for WNV infection rate per 1,000 females using the CDC PooledInfRate 4.0 plug-in for Excel. CDC. 2014. PooledInfRate, version 4.0 http://www.cdc.gov/westnile/resourcepages/mosqSurvSoft.html DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01 etbr) $0.30 Pipette Tips Various $3.00 Gloves Various $2.00 Purification 96 KF Plate $166.17 48 $3.4 6 0.01041666 7 $0.04 Purification Deep well plate $124.80 20 $6.2 4 0.01041666 7 $0.07 Purification KF tip comb $566.00 100 $5.6 6 0.01041666 7 $0.06 TOTAL $15.24 DocuSign Envelope ID: 9AD0AE76-C17E-4B03-BA2C-5449FED65D01